My Laboratory is involved in studying cell signaling events with special reference to insulin secretion and insulin action. Our research integrates physiological and pharmacological approaches with biochemical and molecular biological techniques to study mechanisms underlying development and progression of diabetes, its complications and cardiovascular diseases. This challenging multi-disciplinary research specialization dwells around the following themes:
Insights into biochemistry and molecular biology of diabetes and its complications by studying nutrient-sensing pathways, redox signaling, advanced glycation end products and ion transport mechanisms
Proteomics studies in human skeletal muscle and Adipocytes with special reference to post-translational modifications
Identification of new molecular targets that alters insulin signaling in Adipocytes and Skeletal muscle in Type 2 diabetes
Understanding the link between inflammation /oxidative stress and insulin resistance
Studying intracellular signaling pathways including ER stress involved in cell apoptosis, survival, and inflammatory responses in skeletal muscle cells and beta cells
Exploitation of oxidative stress alterations as therapy for anti-diabetic / antioxidant / anti-inflammatory principles